Confirmed Speakers:

Antonio Salgado

Antonio Salgado

NMR studies on the elucidation of the (unusual) structure of selector-selectand aggregates between daclatasvir and some cyclodextrins

Antonio Salgado got his BSc and MSc in Organic Chemistry at the University of Barcelona (1987) and his PhD at the University of London (1993), also into Organic Chemistry. After few postdoctoral tenures in Spain and abroad, mostly dealing with organic synthesis and characterization of compounds within a drug discovery perspective, in 2006 he joined the Spanish Oncology Research Centre (CNIO), where he stayed until 2012, working as NMR scientist and being fully immersed into the NMR world.

After a spell in the pharmaceutical industry, he was appointed NMR manager at the University of Alcalá (2015), where he has remained ever since. Apart from giving NMR support to fellow researchers, mainly in non-trivial structure elucidation issues, he has maintained scientific collaborations with other teams. One of his main research interest is the determination of the structure of the supramolecular aggregates (complexes) formed by analytes and chiral selectors to rationalize the outcome of enantiomer separations by capillary electrophoresis. He is author or co-author of +65 research papers. He is a reviewer and a member of the Advisory Editorial Board of the “Journal of Pharmaceutical and Biomedical Analysis”. Occasionally, he also lectures about some uses and features of NMR in master courses in his home institution.
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Daniel Monleón Salvadó

Daniel Monleón Salvadó

The role of NMR metabolomics in current molecular epidemiology

Professor of Cell Biology at the Department of Pathology at the University of Valencia and principal investigator of the metabolomics group at INCLIVA and the University of Valencia. More than 20 years researching the biomedical applications of Nuclear Magnetic Resonance (NMR). His research focuses on the study of metabolic profiles to support and help diagnosis, characterization, and selection of therapies in different diseases.

He has performed research stays at the Center for Advanced Biotechnology and Medicine at Rutgers University, State University of New York at Buffalo) and the Albert Einstein College of Medicine. He was the Scientific Manager of a consortium on automatic molecular classification of brain tumors. He has been invited lecturer at various national and international universities, including Rutgers University, the University of Oulu, the Catholic University of Leuven, and the Norwegian University of Science and Technology. He has published over 100 articles in scientific journals including Gut, Hepatology, Cancer Research, Journal of American College of Cardiology, Antioxidant and Redox Signaling, Journal of Biological Chemistry, and Journal of Molecular Biology. He has continuously obtained national and international competitive funding as principal investigator since 2006. According to ResearchGate, his scientific contribution exceeds 95% of the researchers in the world scientific community.
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Douglas V. Laurent

Douglas V. Laurent

NMR Spectroscopic Structural and Stability Studies Pave the Way for Polyproline II Helices as the Next LEGO® for Protein Design

DVL studied in protein folding and stability at Texas A&M and Stanford Universities and joined the MRL in 1997 to learn to apply NMR to characterize proteins. Some proteins do not adopt a well defined fold. These intrinsically disordered proteins or ‘IDPs’ play essential roles in coordinating a myriad of cell processes, but can reek havoc when they misfold to amyloid conformers.

Harmful amyloid states are implicated in over 20 neurodegenerative diseases, for example, the protein TDP-43 forms harmful amyloids implicated in ALS. Paradoxically, the protein CPEB3 forms functional amyloids that are essential to memory conaolidation and learning. Studies are underway to uncover why TDP-43 amyloids are harmful but CPEB3 amyloids are not.
Many ‘disordered’ proteins are rich in glycine and our recent works suggests they may actually adopt folded polyproline II helices. Our ongoing research will test this hypothesis and provide the bases so that polyproline II helices can be designed with useful functions and higher ordered structures for Biotechnology.
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Heike E. Knicker

Heike E. Knicker

Established and advanced solid-state NMR techniques for a better understanding of the nature of biochar

Heike Knicker studied Biology at the University of Regensburg.

After termination of her PhD at the Chair for Biophysics and Physical Biochemistry of the University of Regensburg, a post-doc at the Pennsylvania State University, PA, she managed the solid-state NMR laboratory of the chair of soil science of the Technical University of Munich, Germany. Since 2008, she holds the position of a “Profesora de Investigación” at the IRNAS-CSIC in Seville, Spain. In 2016, she was awarded the Philippe Duchaufour Medal of the European Geosciences Union for outstanding research in the field of soil organic matter (SOM), in particular on the impact of fire on humic materials, and for furthering the knowledge of the origin and properties of pyrogenic soil organic carbon and nitrogen. Already during her master thesis, she applied solid-state NMR spectroscopy for the study of soil biochemical processes which remained a major research interests up to now. She is applying this technique for the investigation of soil organic matter and the impact of soil amendments, the carbon and nitrogen cycle in soils, the impact of vegetation fires and biochars on SOM.
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Janez Plavec

Janez Plavec

NMR structural insights into DNA G-rich repeats

Janez Plavec is the head of the Slovenian NMR Centre at the National Institute of Chemistry and Professor of Structural Biology at the University of Ljubljana (UL). He obtained his diploma in 1987 at the UL Faculty of Chemistry and Chemical Technology and received his M. Sc. degree in 1990 at the same faculty.

His Ph.D. degree was conferred by Uppsala University, Uppsala, Sweden in 1995. He has been Fulbright fellow at Georgia Institute of Technology, Atlanta, GA, USA in 2002. His research interests include studies of structure and dynamics of bio-macro-molecular systems with NMR, structural studies of nucleotides and the building blocks of nucleic acids, protein structure, interactions of small molecules and metal ions with DNA and RNA.
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Juan Manuel Lázaro Martínez

Ann-Christin Pöppler

Solid-state NMR: from small molecules to complex materials

I obtained my academic degree in Biochemistry in 2005 at the University of Buenos Aires (UBA), Argentina. Afterwards, I reached my PhD degree in 2011 (UBA) working in the “Synthesis and Characterization of New Polymeric Materials with Environmental Applications”. After that, I had a postdoctoral training at the University of Córdoba (UNC, Argentina) working in advanced solid-state nuclear magnetic resonance (ss-NMR) experiments for chemical and structural characterization for two years (2011-2013). Also, I had different short stays at the University of Malaga (Spain) for characterization of copper complexes in the period 2015-2020, at the Brazilian Synchrotron Light Laboratory for a SAXS Project (LNLS, Brazil, 2016) and at the University of Durham (2017) for high-resolution ss-NMR experiments with Dr. Hodgkinson.

Nowadays, I have been working as Assistant Professor at the Department of Chemistry (UBA) and as Independent Researcher from The National Scientific and Technical Research Council (CONICET) since 2006 and 2013, respectively. My research project combines the synthesis, characterization and environmental applications of novel copper and cobalt complexes with imidazole/pyridine ligands bearing either gem-diol or carbonyl moieties as well polymeric material/hydrogels and organoclays for homogenous or heterogenous activation of hydrogen peroxide and the concomitant generation of reactive oxygen species for advanced oxidation processes. My main experience relates to the structural characterization of a broad kind of organic/inorganic materials and copper/cobalt complexes by ss-NMR, Electron Paramagnetic Resonance (EPR) and single-crystal X-ray crystallography and their uses in the remediation of wastewater containing dyes, herbicides, drugs and pesticides.
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Krzysztof Kazimierczuk

Krzysztof Kazimierczuk

Non-stationary NMR spectroscopy

Krzysztof Kazimierczuk did his PhD in 2009 at the University of Warsaw, Poland. After a postdoc in the group of prof. Vladislav Orekhov (Swedish NMR Centre, University of Gothenburg) became a head of Laboratory of NMR Spectroscopy in the Centre of New Technologies, University of Warsaw. His research focuses on NMR methods based on novel signal processing concepts.

Over the last decade, prof. Kazimierczuk’s group has developed new approaches to processing the NMR data from multidimensional, diffusion-ordered, time-resolved, pure-shift, and other experiments..
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Laura Castañar

Laura Castañar

Seeking simplicity in spectral complexity? Cutting-edge NMR methods at your disposal

Laura Castañar is a Research Fellow at the University of Manchester working on the development and application of advanced NMR methods for understanding the structure and behaviour of molecules in solution.

Laura Castañar hold a BSc in Chemistry (UCM, 2011) and an MSc in Chemical Sciences (UAB, 2012). She earn her PhD in Chemistry in 2015 (UAB) and after 3.5 years as postdoctoral researcher at the University of Manchester, in 2019 she was awarded a prestigious Dame Kathleen Ollerenshaw Fellowship to start her own research group. She is currently a Research Fellow at the UoM leading a vibrant international research group working on the development of new NMR tools for understanding the structure and behaviour of molecules in solution. These tools produce cleaner and simpler NMR spectra, allowing faster, easier and more reliable extraction of chemical and biological information than current methods. Her outstanding trajectory is reflected in the development of over 20 new NMR methods, the publication of 28 scientific papers (h-index: 16, 729 citations) and in her contributions to international scientific meetings (27 talks, 26 posters). She is a member of the SMASH organising committee and EUROMAR and PANIC scientific committee, and part of the Associate Editorial Board of Magnetic Resonance in Chemistry. She is highly committed to the training of young researchers, having mentored and supervised over 20 researchers, and taught in international NMR Schools, postgraduate training courses and MSc programs. She is also actively involved in the organization and delivery of science outreach activities.
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Luca Unione

Luca Unione

NMR-based strategies to unravel the role of glycans in infectious diseases

Luca Unione studied Chemistry at the University of Napoli Federico II (Italy). He received the PhD in 2016 in Madrid (Spain), in the framework of the ITN-Marie Skłodowska-Curie, working in the field of structural characterization of carbohydrates, glycomimetics and their interactions with glycan binding proteins by NMR.

He carried out a postdoctoral stay in the company Atlas molecular Pharma founded by the Center for Cooperative Research in Bioscience (CIC bioGUNE) in Biscay (Spain). The main aim of the company is to discover first-in-class, innovative therapeutics for the treatment of Rare and Ultra-Rare Diseases. In 2019 he moved to Utrecht University (The Netherlands) as postdoctoral fellow under the International Human Frontier Science Program (HFSP) to master the chemo-enzymatic synthesis of isotopically 13C-labelled glycans to probe Virus-Glycan Interactions by NMR. In 2021 he come back to Spain, and he is currently Senior PostDoc in the Chemical Glycobiology Lab. His research interest is focused on the understanding of the role of glycans as regulators in biomedical processes and the study of glycan–protein interactions through a multidisciplinary approach, with a special focus on NMR techniques.
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Manfred Spraul

Manfred Spraul

Towards the use of NMR in clinical diagnostics

Dr. Spraul obtained his diploma in chemistry in 1979, then did his PHD at the Technical University of Karlsruhe in 1982 and then joined Bruker in 1982 as application chemist for NMR and Liquid Chromatography.

In 1990 he took the lead of the German application team. During this time hyphenated systems were developed and sold worldwide, these are LC-NMR, LC-NMR/MS, UPLC-NMR/MS , SFC- and SFE-NMR. In addition a high throughput flow injection NMR system was developed. He currently is the CTO of the Bruker BioSpin AIC division and responsible for identifying future solutions for NMR in clinical, food and industrial areas. Strong efforts towards IVD-CE of some solution developed are undertaken. He currently is member and initiator of the International COVID research network run in collaboration with the Australian National Phenome Center under Prof. Jeremy Nicholson, with whom he collaborated for more than 35 years. He and his group have participated in 6 EU-projects in the area of clinical research and food authenticity as well as 3 national research projects. He has more than 110 publications in peer reviewed journals and holds 11 patents on NMR technology.
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Nuno Basílio

Nuno Basílio

Using NMR methods to investigate supramolecular systems

Nuno Bası́lio studied Chemistry at the University of the Algarve (Portugal) and obtained his PhD in 2011 from the University of Santiago de Compostela with Prof. Luis Garcı́a Rio and Prof. José Ramón Leis. He then moved to the NOVA University of Lisbon to work as a Postdoctoral Fellow with Prof. Fernando Pina.

Nuno Bası́lio studied Chemistry at the University of the Algarve (Portugal) and obtained his PhD in 2011 from the University of Santiago de Compostela with Prof. Luis Garcı́a Rio and Prof. José Ramón Leis. He then moved to the NOVA University of Lisbon to work as a Postdoctoral Fellow with Prof. Fernando Pina.
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Sanel Suljić

Sanel Suljić

New multiple nuclei and ultra-high resolution/solvent suppression Spinsolve benchtop NMRs

During my doctoral studies, I worked in international and interdisciplinary teams of researchers and was able to successfully establish multi-copper oxidase enzymes as heterogeneous catalysts for stereoselective arylations. Moreover, I successfully combined heterogeneous transition metal catalysis for hydrogenation reactions with enzyme catalysis regarding consecutive onepot procedures in flow towards the synthesis of highly functionalised chiral entities.

Furthermore, I created a fruitful international and interdisciplinary collaboration with a Japanese research group in Osaka employing their organometallic expertise to design artificial copper-complexes mimicking the active sites of metalloenzymes for my synthetic concepts. For the first three years of my studies this project was carried out within the Cluster of Industrial Biotechnology at the Heinrich Heine University Düsseldorf. Lately, I was a member of the SeleCa Research Program at the RWTH Aachen. As a postdoctoral co-worker within the groups of Prof. Dr Marsden, Prof. Dr Blacker, and Prof. Dr Turner at the Universities of Leeds and Manchester, I was part of a collaboration project called Chem21 involving several European universities and pharmaceutical companies with the aim of introducing biotechnology into today’s manufacturing process of medicines. The project was about the development of innovative and sustainable routes towards the syntheses of pharmaceutically relevant chiral amines utilising bio- and organocatalysis as well as base metal catalysis.
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Óscar Millet

Oscar Millet

An NMR-based metabolomic view of the natural history of COVID-19 disease

I obtained a Degree in Chemistry (Univ. Ramon Llull, 1994) and Chemical Engineering (IQS, 1995). After obtaining a Ph D in Organic Chemistry (University of Barcelona, 1999) I joined the group of Lewis Kay in Toronto for a post-doctoral stay (University of Toronto, 2000-2004). I currently am the group leader of the Precision Medicine and Metabolism Laboratory at the CIC bioGUNE.

My research line focuses on the use of nuclear magnetic resonance (NMR) to the study of biologically relevant proteins and enzymes, paying special attention to the delicate balance existing between protein stability and dynamics. Such knowledge is applied for the development of new compounds with therapeutic activity in the field of rare diseases, and it has developed into the creation of a spin-off company, ATLAS Molecular Pharma. Additionally, I am also interested in the NMR-based metabolomics of biofluids for the diagnose of rare and prevalent diseases. I have been awarded the prize of the Real Sociedad Española de Química (young category, 2004) and the Spanish NMR group prize (young category 2005 & 2021) and nominated Academic of the Academy of Medical Sciences of the Basque Country (2016).
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Bruker-GERMN Award for excellence in magnetic resonance

Prizes will be awarded to the best five oral, flash and poster presentations of a values each of 500€, 300€ and 100€, repectively

IMPORTANT DEADLINES

April 1, 2022
Registration Opens
Abstract Submission Opens
September 11, 2022
Submission Deadline
September 18, 2022
Early Registration Ends
October
Registration remains open through the meeting.


Rhodium-103
University of Almería
BRUKER
Specialized Group of Nuclear Magnetic Resonance (GERMN) and Spanish Royal Society of Chemistry (RSEQ)
Palladium-105
Platinum-195
Silver-107