Confirmed Speakers:
Antonio Salgado
NMR studies on the elucidation of the (unusual) structure of selector-selectand aggregates
between daclatasvir and some cyclodextrins
Antonio Salgado got his BSc and MSc in Organic Chemistry at the University of Barcelona
(1987) and his PhD at the University of London (1993), also into Organic Chemistry. After few postdoctoral
tenures in Spain and abroad, mostly dealing with organic synthesis and characterization of compounds within a
drug discovery perspective, in 2006 he joined the Spanish Oncology Research Centre (CNIO), where he stayed until
2012, working as NMR scientist and being fully immersed into the NMR world.
After a spell in the pharmaceutical industry, he was appointed NMR manager at the University of Alcalá (2015),
where he has remained ever since. Apart from giving NMR support to fellow researchers, mainly in non-trivial
structure elucidation issues, he has maintained scientific collaborations with other teams. One of his main
research interest is the determination of the structure of the supramolecular aggregates (complexes) formed by
analytes and chiral selectors to rationalize the outcome of enantiomer separations by capillary electrophoresis.
He is author or co-author of +65 research papers. He is a reviewer and a member of the Advisory Editorial Board
of the “Journal of Pharmaceutical and Biomedical Analysis”. Occasionally, he also lectures about some uses and
features of NMR in master courses in his home institution.
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Daniel Monleón Salvadó
The role of NMR metabolomics in current molecular epidemiology
Professor of Cell Biology at the Department of Pathology at the University of Valencia and
principal
investigator of the metabolomics group at INCLIVA and the University of Valencia. More than 20 years
researching the biomedical applications of Nuclear Magnetic Resonance (NMR). His research focuses on the
study of metabolic profiles to support and help diagnosis, characterization, and selection of therapies in
different diseases.
He has performed research stays at the Center for Advanced Biotechnology and Medicine at Rutgers University,
State University of New York at Buffalo) and the Albert Einstein College of Medicine. He was the Scientific
Manager of a consortium on automatic molecular classification of brain tumors. He has been invited lecturer
at various national and international universities, including Rutgers University, the University of Oulu,
the Catholic University of Leuven, and the Norwegian University of Science and Technology. He has published
over 100 articles in scientific journals including Gut, Hepatology, Cancer Research, Journal of American
College of Cardiology, Antioxidant and Redox Signaling, Journal of Biological Chemistry, and Journal of
Molecular Biology. He has continuously obtained national and international competitive funding as principal
investigator since 2006. According to ResearchGate, his scientific contribution exceeds 95% of the
researchers in the world scientific community.
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Douglas V. Laurent
NMR Spectroscopic Structural and Stability Studies Pave the Way for Polyproline II
Helices as the Next LEGO® for Protein Design
DVL studied in protein folding and stability at Texas A&M and Stanford Universities and
joined the MRL in
1997 to learn to apply NMR to characterize proteins. Some proteins do not adopt a well defined fold. These
intrinsically disordered proteins or ‘IDPs’ play essential roles in coordinating a myriad of
cell processes, but can reek havoc when they misfold to amyloid conformers.
Harmful amyloid states are implicated in over 20 neurodegenerative diseases, for example, the protein TDP-43
forms harmful amyloids implicated in ALS. Paradoxically, the protein CPEB3 forms functional amyloids that
are essential to memory conaolidation and learning. Studies are underway to uncover why TDP-43 amyloids are
harmful but CPEB3 amyloids are not.
Many ‘disordered’ proteins are rich in glycine and our recent works suggests they may actually
adopt folded polyproline II helices. Our ongoing research will test this hypothesis and provide the bases so
that polyproline II helices can be designed with useful functions and higher ordered structures for
Biotechnology.
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Heike E. Knicker
Established and advanced solid-state NMR techniques for a better understanding of the
nature of biochar
Heike Knicker studied Biology at the University of Regensburg.
After termination of her PhD at the Chair for Biophysics and Physical Biochemistry of the University of
Regensburg, a post-doc at the Pennsylvania State University, PA, she managed the solid-state NMR laboratory of
the chair of soil science of the Technical University of Munich, Germany. Since 2008, she holds the position of
a “Profesora de Investigación” at the IRNAS-CSIC in Seville, Spain. In 2016, she was awarded the Philippe
Duchaufour Medal of the European Geosciences Union for outstanding research in the field of soil organic matter
(SOM), in particular on the impact of fire on humic materials, and for furthering the knowledge of the origin
and properties of pyrogenic soil organic carbon and nitrogen.
Already during her master thesis, she applied solid-state NMR spectroscopy for the study of soil biochemical
processes which remained a major research interests up to now. She is applying this technique for the
investigation of soil organic matter and the impact of soil amendments, the carbon and nitrogen cycle in soils,
the impact of vegetation fires and biochars on SOM.
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Janez Plavec
NMR structural insights into DNA G-rich repeats
Janez Plavec is the head of the Slovenian NMR Centre at the National Institute of Chemistry
and Professor of Structural Biology at the University of Ljubljana (UL). He obtained his diploma in 1987 at the
UL Faculty of Chemistry and Chemical Technology and received his M. Sc. degree in 1990 at the same
faculty.
His Ph.D. degree was conferred by Uppsala University, Uppsala, Sweden in 1995. He has been Fulbright fellow at
Georgia Institute of Technology, Atlanta, GA, USA in 2002. His research interests include studies of structure
and dynamics of bio-macro-molecular systems with NMR, structural studies of nucleotides and the building blocks
of nucleic acids, protein structure, interactions of small molecules and metal ions with DNA and RNA.
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Juan Manuel Lázaro Martínez
Solid-state NMR: from small molecules to complex materials
I obtained my academic degree in Biochemistry in 2005 at the University of Buenos Aires
(UBA), Argentina. Afterwards, I reached my PhD degree in 2011 (UBA) working in the “Synthesis and
Characterization of New Polymeric Materials with Environmental Applications”. After that, I had a postdoctoral
training at the University of Córdoba (UNC, Argentina) working in advanced solid-state nuclear magnetic
resonance (ss-NMR) experiments for chemical and structural characterization for two years (2011-2013). Also, I
had different short stays at the University of Malaga (Spain) for characterization of copper complexes in the
period 2015-2020, at the Brazilian Synchrotron Light Laboratory for a SAXS Project (LNLS, Brazil, 2016) and at
the University of Durham (2017) for high-resolution ss-NMR experiments with Dr. Hodgkinson.
Nowadays, I have been working as Assistant Professor at the Department of Chemistry (UBA) and as Independent
Researcher from The National Scientific and Technical Research Council (CONICET) since 2006 and 2013,
respectively. My research project combines the synthesis, characterization and environmental applications of
novel copper and cobalt complexes with imidazole/pyridine ligands bearing either gem-diol or carbonyl moieties
as well polymeric material/hydrogels and organoclays for homogenous or heterogenous activation of hydrogen
peroxide and the concomitant generation of reactive oxygen species for advanced oxidation processes. My main
experience relates to the structural characterization of a broad kind of organic/inorganic materials and
copper/cobalt complexes by ss-NMR, Electron Paramagnetic Resonance (EPR) and single-crystal X-ray
crystallography and their uses in the remediation of wastewater containing dyes, herbicides, drugs and
pesticides.
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Krzysztof Kazimierczuk
Non-stationary NMR spectroscopy
Krzysztof Kazimierczuk did his PhD in 2009 at the University of Warsaw, Poland. After a
postdoc in the group
of prof. Vladislav Orekhov (Swedish NMR Centre, University of Gothenburg) became a head of Laboratory of NMR
Spectroscopy in the Centre of New Technologies, University of Warsaw. His research focuses on NMR methods
based on novel signal processing concepts.
Over the last decade, prof. Kazimierczuk’s group has developed new approaches to processing the NMR data
from multidimensional, diffusion-ordered, time-resolved, pure-shift, and other experiments..
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Laura Castañar
Seeking simplicity in spectral complexity? Cutting-edge NMR methods at your disposal
Laura Castañar is a Research Fellow at the University of Manchester working on the
development and application of advanced NMR methods for understanding the structure and behaviour of molecules
in solution.
Laura Castañar hold a BSc in Chemistry (UCM, 2011) and an MSc in Chemical Sciences (UAB, 2012). She earn her PhD
in Chemistry in 2015 (UAB) and after 3.5 years as postdoctoral researcher at the University of Manchester, in
2019 she was awarded a prestigious Dame Kathleen Ollerenshaw Fellowship to start her own research group. She is
currently a Research Fellow at the UoM leading a vibrant international research group working on the development
of new NMR tools for understanding the structure and behaviour of molecules in solution. These tools produce
cleaner and simpler NMR spectra, allowing faster, easier and more reliable extraction of chemical and biological
information than current methods.
Her outstanding trajectory is reflected in the development of over 20 new NMR methods, the publication of 28
scientific papers (h-index: 16, 729 citations) and in her contributions to international scientific meetings (27
talks, 26 posters). She is a member of the SMASH organising committee and EUROMAR and PANIC scientific
committee, and part of the Associate Editorial Board of Magnetic Resonance in Chemistry. She is highly committed
to the training of young researchers, having mentored and supervised over 20 researchers, and taught in
international NMR Schools, postgraduate training courses and MSc programs. She is also actively involved in the
organization and delivery of science outreach activities.
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Luca Unione
NMR-based strategies to unravel the role of glycans in infectious diseases
Luca Unione studied Chemistry at the University of Napoli Federico II (Italy). He received
the PhD in 2016 in Madrid (Spain), in the framework of the ITN-Marie Skłodowska-Curie, working in the field of
structural characterization of carbohydrates, glycomimetics and their interactions with glycan binding proteins
by NMR.
He carried out a postdoctoral stay in the company Atlas molecular Pharma founded by the Center for
Cooperative Research in Bioscience (CIC bioGUNE) in Biscay (Spain). The main aim of the company is to discover
first-in-class, innovative therapeutics for the treatment of Rare and Ultra-Rare Diseases. In 2019 he moved to
Utrecht University (The Netherlands) as postdoctoral fellow under the International Human
Frontier Science Program (HFSP) to master the chemo-enzymatic synthesis of isotopically 13C-labelled glycans to
probe Virus-Glycan Interactions by NMR. In 2021 he come back to Spain, and he is currently Senior PostDoc in the
Chemical Glycobiology Lab. His research interest is focused on the understanding of the role of glycans as
regulators in biomedical processes and the study of glycan–protein interactions through a multidisciplinary
approach, with a special focus on NMR techniques.
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Manfred Spraul
Towards the use of NMR in clinical diagnostics
Dr. Spraul obtained his diploma in chemistry in 1979, then did his PHD at the Technical University of Karlsruhe
in 1982 and then joined Bruker in 1982 as application chemist for NMR and Liquid Chromatography.
In 1990 he took
the lead of the German application team. During this time hyphenated systems were developed and sold worldwide,
these are LC-NMR, LC-NMR/MS, UPLC-NMR/MS , SFC- and SFE-NMR. In addition a high throughput flow injection NMR
system was developed. He currently is the CTO of the Bruker BioSpin AIC division and responsible for identifying
future solutions for NMR in clinical, food and industrial areas. Strong efforts towards IVD-CE of some solution
developed are undertaken. He currently is member and initiator of the International COVID research network run
in collaboration with the Australian National Phenome Center under Prof. Jeremy Nicholson, with whom he
collaborated for more than 35 years. He and his group have participated in 6 EU-projects in the area of clinical
research and food authenticity as well as 3 national research projects. He has more than 110 publications in
peer reviewed journals and holds 11 patents on NMR technology.
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Nuno Basílio
Using NMR methods to investigate supramolecular systems
Nuno Bası́lio studied Chemistry at the University of the Algarve (Portugal) and obtained
his PhD in 2011 from
the University of Santiago de Compostela with Prof. Luis Garcı́a Rio and Prof. José Ramón Leis. He then
moved to the NOVA University of Lisbon to work as a Postdoctoral Fellow with Prof. Fernando Pina.
Nuno Bası́lio studied Chemistry at the University of the Algarve (Portugal) and obtained his PhD in 2011
from the University of Santiago de Compostela with Prof. Luis Garcı́a Rio and Prof. José Ramón Leis. He then
moved to the NOVA University of Lisbon to work as a Postdoctoral Fellow with Prof. Fernando Pina.
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Sanel Suljić
New multiple nuclei and ultra-high resolution/solvent suppression Spinsolve benchtop NMRs
During my doctoral studies, I worked in international and interdisciplinary teams of researchers
and was able to successfully establish multi-copper oxidase enzymes as heterogeneous catalysts for
stereoselective arylations. Moreover, I successfully combined heterogeneous transition metal catalysis
for hydrogenation reactions with enzyme catalysis regarding consecutive onepot procedures in flow towards
the synthesis of highly functionalised chiral entities.
Furthermore, I created a fruitful international and interdisciplinary collaboration with a Japanese research
group in Osaka employing their organometallic expertise to design artificial copper-complexes mimicking the
active sites of metalloenzymes for my synthetic concepts. For the first three years of my studies this project
was carried out within the Cluster of Industrial Biotechnology at the Heinrich Heine University Düsseldorf.
Lately, I was a member of the SeleCa Research Program at the RWTH Aachen. As a postdoctoral co-worker within the
groups of Prof. Dr Marsden, Prof. Dr Blacker, and Prof. Dr Turner at the Universities of Leeds and Manchester, I
was part of a collaboration project called Chem21 involving several European universities and pharmaceutical
companies with the aim of introducing biotechnology into today’s manufacturing process of medicines. The project
was about the development of innovative and sustainable routes towards the syntheses of pharmaceutically
relevant chiral amines utilising bio- and organocatalysis as well as base metal catalysis.
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Óscar Millet
An NMR-based metabolomic view of the natural history of COVID-19 disease
I obtained a Degree in Chemistry (Univ. Ramon Llull, 1994) and Chemical Engineering (IQS,
1995). After obtaining a Ph D in Organic Chemistry (University of Barcelona, 1999) I joined the group of Lewis
Kay in Toronto for a post-doctoral stay (University of Toronto, 2000-2004). I currently am the group leader of
the Precision Medicine and Metabolism Laboratory at the CIC bioGUNE.
My research line focuses on the use of nuclear magnetic resonance (NMR) to the study of biologically relevant
proteins and enzymes, paying special attention to the delicate balance existing between protein stability and
dynamics. Such knowledge is applied for the development of new compounds with therapeutic activity in the field
of rare diseases, and it has developed into the creation of a spin-off company, ATLAS Molecular Pharma.
Additionally, I am also interested in the NMR-based metabolomics of biofluids for the diagnose of rare and
prevalent diseases. I have been awarded the prize of the Real Sociedad Española de Química (young category,
2004) and the Spanish NMR group prize (young category 2005 & 2021) and nominated Academic of the Academy of
Medical Sciences of the Basque Country (2016).
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