Speakers2 – GERM 2022

Ann-Christin Pöppler

Title: Taking up the chase with NMR Spectroscopy – From structural insights into solid drug-polymer formulations to their fate in biorelevant media

Ann-Christin is a trained chemist with a PhD in inorganic chemistry (University of Göttingen, 2013), where she worked with NMR in solution and anisotropic media. She was introduced to the world of solid-state NMR and to a smaller extent also to XRD and computational methods through her postdoctoral experiences.

After postdoctoral stays at the Max Planck Institute for Biophysical Chemistry (Göttingen, 2014) and the Department of Physics at Warwick University (UK, 2014-2016), she had the great opportunity to start her own research group as a Junior Professor of Organic Structural Chemistry at the University of Würzburg. Since October 2016 she is combining the different research areas and wants to use as well as expand the versatile NMR toolbox to look at polymeric drug delivery systems with the aim of gaining an increased understanding of the structure and behaviour of these mostly amorphous host-guest systems in the solid state and in biorelevant media. Apart from sitting at the spectrometer, Ann-Christin very much enjoys teaching and training of students both in the lecture hall as well as in the workgroup.

More

Antonio Salgado

Title: – Soon –

Daniel Monleón Salvadó

Title: The role of NMR metabolomics in current molecular epidemiology

Professor of Cell Biology at the Department of Pathology at the University of Valencia and principal investigator of the metabolomics group at INCLIVA and the University of Valencia. More than 20 years researching the biomedical applications of Nuclear Magnetic Resonance (NMR). His research focuses on the study of metabolic profiles to support and help diagnosis, characterization, and selection of therapies in different diseases.

He has performed research stays at the Center for Advanced Biotechnology and Medicine at Rutgers University, State University of New York at Buffalo) and the Albert Einstein College of Medicine. He was the Scientific Manager of a consortium on automatic molecular classification of brain tumors. He has been invited lecturer at various national and international universities, including Rutgers University, the University of Oulu, the Catholic University of Leuven, and the Norwegian University of Science and Technology. He has published over 100 articles in scientific journals including Gut, Hepatology, Cancer Research, Journal of American College of Cardiology, Antioxidant and Redox Signaling, Journal of Biological Chemistry, and Journal of Molecular Biology. He has continuously obtained national and international competitive funding as principal investigator since 2006. According to ResearchGate, his scientific contribution exceeds 95% of the researchers in the world scientific community.

More

Douglas V. Laurent

Title: NMR Spectroscopic Structural and Stability Studies Pave the Way for Polyproline II Helices as the Next LEGO® for Protein Design

DVL studied in protein folding and stability at Texas A&M and Stanford Universities and joined the MRL in 1997 to learn to apply NMR to characterize proteins. Some proteins do not adopt a well defined fold. These intrinsically disordered proteins or ‘IDPs’ play essential roles in coordinating a myriad of cell processes, but can reek havoc when they misfold to amyloid conformers.

Harmful amyloid states are implicated in over 20 neurodegenerative diseases, for example, the protein TDP-43 forms harmful amyloids implicated in ALS. Paradoxically, the protein CPEB3 forms functional amyloids that are essential to memory conaolidation and learning. Studies are underway to uncover why TDP-43 amyloids are harmful but CPEB3 amyloids are not.
Many ‘disordered’ proteins are rich in glycine and our recent works suggests they may actually adopt folded polyproline II helices. Our ongoing research will test this hypothesis and provide the bases so that polyproline II helices can be designed with useful functions and higher ordered structures for Biotechnology.

More

Janez Plavec

Title: – Soon –

Krzysztof Kazimierczuk

Title: Non-stationary NMR spectroscopy

Krzysztof Kazimierczuk did his PhD in 2009 at the University of Warsaw, Poland. After a postdoc in the group of prof. Vladislav Orekhov (Swedish NMR Centre, University of Gothenburg) became a head of Laboratory of NMR Spectroscopy in the Centre of New Technologies, University of Warsaw. His research focuses on NMR methods based on novel signal processing concepts.

Over the last decade, prof. Kazimierczuk’s group has developed new approaches to processing the NMR data from multidimensional, diffusion-ordered, time-resolved, pure-shift, and other experiments..

More

Laura Castañar

Title: – Soon –

Luca Unione

Title: – Soon –

Manfred Spraul

Title: – Soon –

Nuno Basílio

Title: Taking up the chase with NMR Spectroscopy – From structural insights into solid drug-polymer formulations to their fate in biorelevant media

Nuno Bası́lio studied Chemistry at the University of the Algarve (Portugal) and obtained his PhD in 2011 from the University of Santiago de Compostela with Prof. Luis Garcı́a Rio and Prof. José Ramón Leis. He then moved to the NOVA University of Lisbon to work as a Postdoctoral Fellow with Prof. Fernando Pina.

More